49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have officially put their playoff destiny in their own hands.

Indianapolis Colts QB Philip Rivers shared a memorable on-field exchange with Dee Winters after a game-sealing pick-six on MNF.

The Indianapolis Colts are dealing with another injury along the offensive line, early in their Monday Night matchup with the San Francisco 49ers. On the second play of the game, center Tanor Bortolini exited the game. He is being evaluated for a concussion.

San Francisco 49ers tight end George Kittle suffered an ankle injury during the Indianapolis Colts on Dec. 23. Here's what we know so far.

Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis Colts face the San Francisco 49ers.

Indianapolis Colts wide receiver Alec Pierce (14) catches a touchdown pass against San Francisco 49ers cornerback Darrell Luter Jr. during the first half of an NFL football game, Monday, Dec. 22, 2025, in Indianapolis. Credit: AP/AJ Mast

The Indianapolis Colts have lost starting center Tanor Bortolini for the rest of the game against the San Francisco 49ers in a 'gotta have it' battle.

On "49ers Postgame Live," Matt Maiocco hands out grades from San Francisco's 48-27 win over the Indianapolis Colts on Monday at Lucas Oil Stadium.Grading 49ers' performance on offense, defense in strong Week 16 win vs.