A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan.

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

• Chloroplasts retain part of their ancestral genomes and the machinery for expression of those genomes. The nucleus-encoded chloroplast RNA helicase INCREASED SIZE EXCLUSION LIMIT2 (ISE2) is required ...

Every person starts as just one fertilized egg. By adulthood, that single cell has turned into roughly 37 trillion cells, many of which keep dividing to create the same amount of fresh human cells ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

For the first time, the structure of a DNA enzyme complex implicated in infertility and cancer has been obtained using cryo-electron microscopy (cryo-EM). A collaboration of researchers, led by ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both sides of the DNA helix are cut at once. Healthy cells can normally fix ...