Hearts melt at how golden puppy's rare "somatic mutation" makes him look

Bernie the golden retriever was born with black spots and stripes in his fur.
ascopubs.org

Impact of germline vs somatic BRCA mutation status on the efficacy of rucaparib vs physician’s choice in the TRITON3 study of patients with metastatic castration-resistant ...

Phase 1b/2 KEYNOTE-365 cohort I: Pembrolizumab (pembro) plus carboplatin and etoposide chemotherapy (chemo) or chemo alone for metastatic neuroendocrine prostate cancer (NEPC). This is an ASCO Meeting ...
ascopubs.org

Carboplatin in patients with metastatic castration-resistant prostate cancer harboring somatic or germline homologous recombination repair gene mutations: Phase II single-arm ...

A phase 1b/2 study evaluating the activity of tinengotinib in combination with androgen receptor pathway inhibitors (ARPIs) in patients with metastatic castration resistant prostate cancer (mCRPC). A ...
The American Journal of Managed Care

Managing Germline Mutations in Hereditary Breast Cancer Risk

Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM also contribute to ...
Labroots

Unravelling germline variants in hematology-oncology patients: Management in the era of WGS and NGS

Join us for a comprehensive exploration of germline variants in hematology-oncology patients, navigating the complexities of management in the age of whole genome and next-generation sequencing. Our ...